| Unlock This | How to Unlock |
| Bloody Palace Mode | Complete the game as Dante or use a memory card with a DMC3 save data |
| Coatless Dante | Complete Easy or Normal mode |
| Coatless Vergil | Beat easy with vergil |
| Corrupt Vergil | Clear Hard |
| DMC1 Dante | Complete Normal mode |
| Easy Mode | Die three times in normal mode. |
| Hard Mode | completing Normal mode |
| Super Corrupt Vergil | Clear VMD |
| Super Dante | Finish The Game On DMD Difficulty |
| Super Vergil | Complete Bloody Palace |
| Vergil Mode | Complete the game as Dante or use a memory card with a DMC3 save data |
| Very Hard Difficulty | You must beat the Hard level |
