| Unlock This | How to Unlock |
| Bonus Mission: Latveria 1 |
Beat the game on Medium |
| Bonus Mission: Latveria 2 |
Beat the game on Hard |
| Concept 1: Enemy Drawings |
Purchase from 'Upgrades Menu' 1000pts |
| Concept 2: Boss Monster Drawings |
Purchase from 'Upgrades Menu' 1000pts |
| Concept 3: Character Pencil Sketches (Marvel) |
Purchase from 'Upgrades Menu' 1000pts |
| Concept 4: 'Ultimate Fantastic 4' Setches (Marvel) |
Purchase from 'Upgrades Menu' 1000pts |
| Concept 5: 'Ultimate Fantastic 4' Comic Panels |
Purchase from 'Upgrades Menu' 1000pts |
| Ultimates 1: 'Ultimate Fantastic 4' Pannel #1 |
Purchase from 'Upgrades Menu' 2500pts |
| Ultimates 2: 'Ultimate Fantastic 4' Pannel #2 |
Purchase from 'Upgrades Menu' 2500pts |
| Ultimates 3: 'Ultimate Fantastic 4' Pannel #3 |
Purchase from 'Upgrades Menu' 2500pts |
| Ultimates 4: 'Ultimate Fantastic 4' Pannel #4 |
Purchase from 'Upgrades Menu' 2500pts |
| Ultimates 5: 'Ultimate Fantastic 4' Pannel #5 |
Purchase from 'Upgrades Menu' 2500pts |
| Covers 1: Classic 'Fantastic 4' Cover #1 |
Purchase from 'Upgrades Menu' 2500pts |
| Covers 2: Classic 'Fantastic 4' Cover #2 |
Purchase from 'Upgrades Menu' 2500pts |
| Covers 3: Classic 'Fantastic 4' Cover #3 |
Purchase from 'Upgrades Menu' 2500pts |
| Covers 4: Classic 'Fantastic 4' Cover #4 |
Purchase from 'Upgrades Menu' 2500pts |
| Covers 5: Classic 'Fantastic 4' Cover #5 |
Purchase from 'Upgrades Menu' 2500pts |
| Covers 6: Classic 'Fantastic 4' Cover #6 |
Purchase from 'Upgrades Menu' 2500pts |
| Bios 1: Biographies of the Fantastic 4 |
Purchase from 'Upgrades Menu' 2000pts |
| Bios 2: Biographies of the classic Fantastic 4 villains #1 |
Purchase from 'Upgrades Menu' 2000pts |
| Bios 3: Biographies of the classic Fantastic 4 villains #2 |
Purchase from 'Upgrades Menu' 2000pts |
| Bios 4: Biographies of original 'Fantastic 4' enemies #1 |
Purchase from 'Upgrades Menu' 2000pts |
| Bios 5: Biographies of original 'Fantastic 4' enemies #2 |
Purchase from 'Upgrades Menu' 2000pts |
| Interviews 1: Michael Chiklis (The Thing) Interview |
Purchase from 'Upgrades Menu' 5000pts |
| Interviews 2: Loan Gruffudd (Mr. Fantastic) Interview |
Purchase from 'Upgrades Menu' 5000pts |
| Interviews 3: Zak Penn & Marty Signore (writers) Interview #1 |
Purchase from 'Upgrades Menu' 5000pts |
| Interviews 4: Chris Evans (Human Torch) Interview |
Purchase from 'Upgrades Menu' 5000pts |
| Interviews 5: Jessica Alba (Invisible Woman) Interview |
Purchase from 'Upgrades Menu' 5000pts |
| Interviews 6: Zak Penn & Marty Signore (writers) Interview #2 |
Purchase from 'Upgrades Menu' 5000pts |
| Interviews 7: Julian McMahon (Dr. Doom) Interview |
Purchase from 'Upgrades Menu' 5000pts |
| F4 Secret 1: Stan Lee Interview #1 |
Collect 9 F4 Icons |
| F4 Secret 2: Stan Lee Interview #2 |
Collect 13 F4 Icons |
| F4 Secret 3: Developer Interview #1 |
Collect 22 F4 Icons |
| F4 Secret 4: Stan Lee Interview #3 |
Collect 26 F4 Icons |
| F4 Secret 5: Stan Lee Interview #4 |
Collect 29 F4 Icons |
| F4 Secret 6: Developer Interview #2 |
Collect 33 F4 Icons |
| F4 Secret 7: Stan Lee Interview #5 |
Collect 35 F4 Icons |
