| Unlock This | How to Unlock |
| Alternate Title Screen | Complete the main game once. |
| Ashley's knight armor outfit | Beat Seperate Ways |
| Chicago Typewriter (Main Game) | Beat Seperate Ways |
| Chicago Typewriter (Seperate Ways) | Beat Assignment Ada |
| Handcannon | Have each mercenary get a five star rating on all of the stages |
| Infinite Rocket Launcher | Beat the game once |
| Leon's gangster outfit | Beat Seperate Ways |
| Matilda | Beat the game once |
| Mercenaries | Beat the main game once |
| Movie Browser | Beat the game |
| P.R.L 412 | Beat Professional Mode |
| Professional Difficulty | Beat the main game once |
| Seperate Ways (Ada's Bonus Game) | Beat the main game once |
| Seperate ways movie browser | Beat seperate ways once |
| Special clothes for Leon, Ada, and Ashley | Beat the main game |
| Ada Wong | Score 4000 or more on Game Type A. Alternately, hit all of the targets on Game Type A |
| Ashley Graham | Score 3000 or more on Game Type A |
| Bella Sisters | Score 4000 or more on Game Type B. Alternately, hit all of the targets on Game Type B |
| Don Diego | Score 3000 or more on Game Type B |
| Don Esteban | Score 3000 or more on Game Type B |
| Don Jose | Score 3000 or more on Game Type B |
| Don Manuel | Score 3000 or more on Game Type B |
| Don Pedro | Score 4000 or more on Game Type C. Alternately, hit all of the targets on Game Type C |
| Dr. Salvador | Score 3000 or more on Game Type B |
| Isabel | 3000 or more points in Game D. |
| J.J. | 4000 or more points in Game D. Hit all targest in Game D except Ashley. |
| Leader Zealot | Score 3000 or more on Game Type C |
| Leon with Handgun | Score 3000 or more on Game Type A |
| Leon with Rocket Launcher | Score 3000 or more on Game Type A |
| Leon with Shotgun | Score 3000 or more on Game Type A |
| Luis Sera | Score 3000 or more on Game Type A |
| Maria | 3000 or more points in Game D. |
| Merchant | Score 3000 or more on Game Type C |
| Soldier w/ dynamite,Soldier w/ hammer,Soldier w/ stun-rod | 3000 or more points in Game D. |
| Zealot with Bowgun,Zealot with Scythe,Zealot with Shield | Score 3000 or more on Game Type C |
